pergularia daemia medicinal usessales compensation surveys

2018;10:103. However, only 70007500 plant varieties among them are in commercial use. Cytotoxic activity of Pergularia daemia against ovarian cancer cell lines OAW-42 and PA-1. Active status on phytochemistry and pharmacology of Pergularia daemia Forsk. Antioxidants are the compounds that are capable of neutralizing free radicals by interfering with oxidation process, chelating catalytic metals and acts as oxygen scavengers [48]. alcoholic (50%), petroleum ether, ethyl acetate and n-butanol extract of Pergularia daemia indicates presence of flavonoids, steroids, alkaloids, triterpens and saponin. Traditionally the plant P.daemia was used as anthelmintic, laxative, antipyretic and expectorant, and was also used to treat infantile diarrhoea and malarial intermittent fevers and possesses stomachic, laxative and diuretic properties, useful in cough, biliousness and sore eyes (1-3). (15) was employed, with modification, for the assessment of diuretic activity. India is the one of the leading exporters of herbs and value added extracts of medicinal herbs (Export of Herbs and Herbal Products, 2019). PubMed Central Check your mobile for SMS (Didn't get the message, repeat Step 1). Have two times a day. Very recently Hina and Rose [56] determined in vitro anti-inflammatory activity of P. daemia ethanolic extracts in leaf and root by human red blood cell (HRBC) membrane stabilization method. Santosh MK, Sharanabasappa GK, Shaila D, Seetharam YN, Sanjeevarao I. Phytochemical studies on Bauhinia racemosa lam., Bauhinia purpurea Linn. Cite this article. Whereas, ethanolic extracts exhibited late abortifacient activity with 600mg/kg. Molecules. [36] identified a variety of cardenolide including uscharidin and calotoxin in seed extract. Mini-Rev Med Chem. This decoction also treats urinary tract problems and also can be taken for severe stomach pain. PubMed Animals were kept at room temperature of 35 1C throughout the experiment. Patwardhan B, Warude D, Pushpangadan P, Bhatt N. Ayurveda and traditional Chinese medicine: a comparative overview. Importantly plant extracts also affect the urinary electrolyte excretion. Both aqueous and ethanolic extracts at the dose of 100 and 200mg/kg caused significant inhibition in the biochemical markers of SGOT and SGPT. It is also used in treating gastric ulcers, uterine and menstrual complaints. Also ethanolic extract effectively inhibited the formation of peroxides and hydrogen peroxides. 1). J Chromatogr A. Thus, medicinal plants are sources of new antiepileptic drugs. Importantly, anti-inflammatory activities of phytocompounds have been described in earlier reports and some of them are in preclinical trials at present [16]. Pharmacological datas obtained from scientific journals published from 2000 to 2020. 2001;73(3):28590. Pandey M, Rastogi S, Rawat A. Indian traditional ayurvedic system of medicine and nutritional supplementation. (Asclepiadaceae) is a traditionally reported medicinal herb used to treat joint pain and arthritis. 3. Liver is an incredible organ and is fundamental chemical laboratory of our body which plays a crucial role in the metabolism and detoxification of various chemicals and toxins enter into the body. Frawley D, Ranade S. Ayurveda, natures medicine. Phytother Res. 2012;3:25867. [13] identified and reported that P. daemia extracts consist of five flavonoids (formononetin, qurecetin, chrysoeriol, taxifolin and naringenin) which has anti-arthritic activity against complete freunds adjuvant (CFA) induced rat model [13]. 2016;80:24452. 2007;4:2131. Exp Toxicol Pathol. But the scientific parameters are not yet available to identify the true plant material. 2001;33(4):2606. J Med Plant Economic Develop. https://doi.org/10.1016/S0021-9673(04)01409-8. Do you know this herb by any other name ? volume7, Articlenumber:60 (2021) Velparuthi also showed significant antibacterial and anti fungal properties and along with it antioxidant properties too, making it very valuable for treating stress related diseases. https://doi.org/10.1016/0955-2863(95)00168-9. Jain SC, Jain R, Mascolo N, Capasso F, Vijayvergia R, Sharma RA, Mittal C. Ethnopharmacological evaluation of Pergularia daemia (Forsk) Chiov. Other informations obtained from local Indian taxonomical books, Ph.D. thesis and local survey. These data indicate that they are not acting as potassium sparing diuretics (18, 19). ]. Shahidi F, McDonald J, Chandrasekara A, Zhong Y. Phytochemicals of foods, beverages and fruit vinegars: chemistry and health effects. PubMed You can also grow this plant in your garden and it needs very little maintenance. Bioactive compounds involved in pharmacological activities due to its antioxidant, anti-inflammatory and other related properties in human. Herbal based therapies by secondary metabolites from plant extracts known to reduce the disease severity without side effects for cancer treatment. 2005;19(11):146984. Against carbon tetrachloride-induced toxicity in rats. 2014;3(1):2934. 2002;2(1):803. Phytochem. ), ethanolic extract (400 mg/Kg), pet ether extract (400 mg/Kg), ethyl acetate extract (400 mg/Kg) and n-butanol extract (400 mg/Kg) respectively. https://doi.org/10.1016/S0031-9422(00)94717-4. Ananth, D.A., Deviram, G., Mahalakshmi, V. et al. Kumar B, Yadav DK, Govindarajan R, Pushpangadan P. Wound healing activity of Pergularia daemia (Forsk) Chiov. 1). In recent decades, the development of scientific research in pharmacology and phytochemistry of medicinal plants lead to the next level of herbal medicines. ): the Ayurvedic wonder. CAS Further the urine was slightly acidified (Table 3). It is used for the treatment of different health issues such as diarrhea, cough, asthma, rheumatism, bronchitis, skin condition, piles, liver disorder, and uterus related problems. Iran J Pharm Res. Evid-Based Complement Altern Med. CAS Calder PC, Albers R, Antoine J-M, Blum S, Bourdet-Sicard R, Ferns G, et al. 2014;7(5):8995. Pharmacophore. P. daemia extracts induced paralysis followed by the death in the warms with a concentration of 100mg/ml exhibiting (P<0.01) anthelmintic activity compared to that of standard drug. Abascal K, Ganora L, Yarnell E. The effect of freeze-drying and its implications for botanical medicine: a review. Hence, different plants have been studied using recent scientific approaches to classify various biological compounds of these medicinal plants. Pergularia daemia hydro-ethanolic extract protects against The leaves are thin, opposite, membranous, 3-9 cm long, broadly ovate, orbicular or deeply cordate, acute or short-acuminate at apex, pubescent beneath. 2005;4(2):915. Highly reactive trichloro free radical was generated by CCl4, which attacks polyunsaturated fatty acids. P. daemia is a perennial climber, traditionally reported for the treatment in a variety of diseases. official website and that any information you provide is encrypted https://herbpathy.com/Uses-and-Benefits-of-Pergularia-Daemia-Cid990, [Note: You are requested to write correct English only. The prime reason is that other system of medicine although effective and it has a number of side effects that often lead to serious complications. In similar way, the root extracts of P. daemia showed 58.89% of inhibition than the leaf extracts which showed 53.33%. Sarkodie JA, Squire SA, Bekoe EO, Domozoro CYF, Kretchy IA, Ahiagbe MKJ, et al. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Hepatoprotective activity of extracts from Pergularia daemia (Forsk) against carbon tetrachloride-induced toxicity in rats. Careers, Unable to load your collection due to an error. Bioactive phytocompounds are very limited source as these are not feasible to obtain from all plant types. These secondary metabolites are known for their pharmacological properties [4, 5]. 2016;2:1131412. Vaithiyanathan V, Mirunalini S. Assessment of anticancer activity: A comparison of dose response effect of ethyl acetate and methanolic extracts of Pergularia daemia (Forsk). P. daemia is the one of the less studied and scientifically reported medicinal plant. (12) reported the presence of various triterpenes and steroidal compounds (3). 2008;23(6):97684. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Senthilkumar M, Gurumoorthi P, Janardhanan K. Antibacterial potential of some plants used by tribals in Maruthamalai hills, Tamil Nadu. Loop diuretics inhibit the Na+/K+/Cl- co-transporter system in the thick ascending loop of nephron, thereby increasing natriuresis and kaleuresis (18, 19) and also cause acidification of urine (18, 20). PDF Pergularia Daemia- As an Excellent Phytomedicine Rakhit S, Dhar MM, Anand N, Dhar ML. Khorombi TE. The datasets supporting the conclusions of this article are included within the article. Particularly ethyl acetate extract (300mg/kg b.w.) However, medicinal plants like P. daemia have curative effects with least side effects [13]. (Asclepiadaceae) is used traditionally as an anthelmintic, laxative, antipyretic, and expectorant, and also used to treat malarial intermittent fever. J Ethnopharmacol. Methanolic extract of P. daemia areal part was highly potent in neutralizing ABTS, DPPH and nitric oxide free radicals and was comparable with that of gallic acid. Biofactors. To obtain the diuretic activity, the diuretic action of the extract is compared to that of the standard drug in the test group (16). Collect fresh leaves and use approximately 5 grams of the leaves and grind it to a paste with water and consume it for a week in the early morning. J Gastroenterol Hepatol. And Hardwickia binate Roxb. Mirunalini et al. Similarly, root extract is used as an abortifacient, emetic and also used to treat against asthma, constipation and gonorrhoea. and transmitted securely. Nikajoo LT. Analgesic activity of aqueous and alcohol root extracts of Pergularia daemia (Forsk.) Other extracts such as n-butanol, benzene and chloroform showed 16.83%, 13.96% and 15.08% respectively at the same concentration [54]. https://doi.org/10.1111/j.1440-1746.2008.05333.x. Lpez-Lzaro M. Distribution and biological activities of the flavonoid luteolin. Acute oral toxicity study was performed as per OECD-423 guidelines (acute toxic class method) (14). 2005;2(4):46573. Amelioratory effect of flavonoids rich Pergularia daemia extract against CFA induced arthritic rats. Methodology With the support of electronic databases such as Science Direct, Google Scholar, Mendeley, Scirus and PubMed central. [73] reported that ameliorative effect of P. daemia hydro alcoholic leaf extracts against antituberculosis drugs (ATDs) induced liver injury. Recent research indicated that natural antioxidants capable of preventing oxidative stress related liver problems [65,66,67]. Food Chem Toxicol. Provided by the Springer Nature SharedIt content-sharing initiative. Kumar et al. 2). P. daemia extract, contains several phytochemicals, especially rich in flavonoids. If mortality is not observed, the procedure would be repeated for further higher doses such as 50, 300 and 2000 mg/Kg body weight. They confirmed by membrane stabilization assay, and the highest % activity was observed in leaf (54.55%) than root (45.55%). Sinha S, Dogra J. 1954;18B:4226. P. daemia is a perennial climber, traditionally reported for the treatment in a variety of diseases. Flavonoids are the most familiar and extensively distributed group of plant phenolics. The .gov means its official. Leaves are thin 510 by 3.89cm in length and heart or broadly ovate or glabrous shaped and margins margin ciliate hairy and cordate at the base petioles 26.3cm in length, pubescent. The animals were kept fasting for overnight providing only water, after which the extract (50% alcoholic extract) was administered orally at the dose level of 5 mg/Kg body weight by gastric intubation and observed for 14 days. Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. Vegetative parts of P. daemia reported for hyperoside (flavonol) in the dried stem and flavonoids and saponins in fresh shoots and flowers [37, 38]. [63] revealed that that P. daemia extract has anti-hyperglycaemic activity against STZ-induced rat models. In addition, they mentioned small structural modification of triterpenoids as the ability to establish an oval drug against cancer [60]. The author(s) read and approved the final manuscript. Terms and Conditions, These flavonoids have the potential inhibit the pro inflammatory mediators and other inflammatory agents (Fig. The death of the cancer cell initiates ROS generation and lipid peroxidation (LPO) in intra cellular region and damages DNA by initiating apoptosis in KB cell [20]. The authors declare that they have no competing interests. Meena AK, Bansal P, Kumar S. Plants-herbal wealth as a potential source of ayurvedic drugs. The IC50 values was found to be 6.27g/ml (ethanol), 17.78g/ml (ethyl acetate) and 22.49g/ml (n-hexane) and the standard ascorbic acid (5.67g/ml) extracts, respectively. 1993;1(6):31527. This extract treats asthma and all cold related problems like bronchitis. The leaf latex is used as pain killer and as a relief for toothache [7]. In Ayurvedic system, herbal compositions were mostly prepared through polyherbal formulations. Int J Mol Sci. https://doi.org/10.1021/jf0201327. Cogent Food Agric. Fresh leaf extract when mixed with lime or ginger exhibited strong activity against rheumatic swelling [12]. Similarly, aqueous extract showed paralysis and time of death was (32.330.67 and 76.190.56min) for roundworm, (20.910.31 and 30.890.45min) for earthworm and (64.440.54 and 172.140.81min) for tapeworm respectively. Extract the juice of Pergularia Daemia from the leaves. 2004;42(4):60917. Golam S, Gafur MA, Shah MAB, Khurshid AHM, Biswas MHU, Hassan P, Mannan A, Khan OF, Chowdhury AKA. Pergularia Daemia Herb Uses, Benefits, Cures, Side Effects, Nutrients Dhananjayan et al. They were fasted 18 h prior to the test, with free access to water. Phytochemical constituents such as polyphenolic compounds, tannins, terpenoids are reported to be effective against various disorders [8]. These compounds are reported to prevent free radical mediated oxidative damage and thereby reducing the risk of causing various degenerative diseases and disorders [44]. Antifertility activity of the alkaloidal fraction of Pergularia daemia. On comparison with other parts in plant, leaf and stem extract exhibited the vast flavonoids content. Mass spectrometry (MS) is mainly used for both quantitative and qualitative analysis of biomolecules. The extracts were also unlikely to be acting as thiazide diuretics: these only increase urinary K+ level and alter the urinary Na+/K+ ratio (17). FOIA In P. daemia plant extract (whole plant, leaves, stem and root) consist of different chemical compounds. Subramanya S, Venkataraman B, Meeran M, Goyal S, Patil C, Ojha S. Therapeutic potential of plants and plant derived phytochemicals against acetaminophen induced liver injury. 2009;101(Suppl):S145. Piles Tumors Action of Pergularia Daemia Effective Analgesic Anthelmintic Clin Phytosci 7, 60 (2021). Shahidi F. Antioxidant factors in plant foods and selected oilseeds. Basic principles of pharmaceutical science in Ayurvda. Antioxidant and antimicrobial capacities of ethanolic extract of Pergularia daemia leaves: a possible substitute in diabetic management. The results show that alcoholic extract, ethyl acetate extract and n-butanol extract of Pergularia daemia (Table 3) affects urinary electrolyte. extract in vitro and in vivo experiments on hamster buccal pouch carcinogenesis. Int J Pharm Pharm Sci. Many of these phytochemicals have beneficial effects on long term when consumed by humans and can be used effectively to treat various chronic diseases. With the support of electronic databases such as Science Direct, Google Scholar, Mendeley, Scirus and PubMed central. Well known examples of phytocompounds include phenols, flavonoids, phenolic glycosides, saponins and cyanogenic glycosides [39, 40]. The data were expressed as mean SEM. Latex of uthamani can be applied for treating boils and wounds. Chromatographic techniques are widely used for identification of bioactive compounds from plant extracts. Dai J, Mumper RJ. In: The science of flavonoids: Springer; 2006. p. 21338. Urinary electrolyte excretion was also affected by the extracts: the alcoholic, ethyl acetate and n-butanol extract caused an increase in the urinary excretion of sodium and potassium ions. Steroidal fraction of 200mg/kg showed significant activity against female mice at the stage of pre-implantation. The whole plant, Pergularia daemia (Family: Asclepediaceae), was extracted with 50% alcohol and a fresh batch of the plant material was successively extracted with petroleum ether, ethyl acetate and n-butanol to determine its diuretic activity.The diuretic activity of the different extracts at a dose of 400 mg/Kg was assessed orally in rats with furosemide as a standard drug using Lipschitzs test. https://doi.org/10.1016/j.etp.2009.05.008. Sadik MG, Gafur M, Bhuiyan MSA, Rahman MM, Biswas HU. Qualitative analysis of phytochemicals including flavonoids, terpenoids, phytosterols, proteins, amino acids and saponins have been isolated and identified from different parts of P. daemia. Phytochemicals such as phenols, alkaloids, flavonoids, phytosterols, saponins, tannins and triterpenes found in the leaf extract might be responsible for the observed antioxidant activities [17, 50, 51]. However, there are no scientific reports about anti-arthritic activity of P. daemia methanolic extract on rats as animal model. PubMed 3c). Osorio FV, Teitelbaum I. Mechanisms of defective hydroosmotic response in chronic renal failure. PDF Phytochemical Studies on the Leaves of Pergularia Daemia Collected from Menses Scanty Polycystic O. Liver injury or damage is a well known disease which can be caused by excessive production of ROS that lead to the hepatic cells and tissue damage. Authors suggested that polyphenolic compounds principally triterpenoids play a vital role against growth of cancer cells. The plant kingdom as a source of anti-ulcer remedies. Sureshkumar and Mishra [70] suggested that P. daemia leaf ethanolic extract containing flavonoids and triterpenoids are the most responsible for the hepatoprotective activity. Article Adesanoye OA, Farombi EO. Medicinal plants play a significant role in the progress of persuasive therapeutic agents. Inflammatory disease processes and interactions with nutrition. Libby P. Inflammatory mechanisms: The molecular basis of inflammation and disease. Medicinal and aromatic plants are rich in bioactive secondary metabolites like phenolic acids, flavonoids, alkaloids, glycosides, phytosterols, terpenoids, tannins. Usman MRM, Salgar SD, Pati SA. Their findings also illustrated anti-inflammatory activity by membrane stabilization method in the ethanolic leaf (54.55%) and root (45.55%) extract at a concentration of 300g/ml and produced most significant stabilization compared to that of standard drug diclofenac sodium (72.73%) at 100g/ml concentration. Pergularia is a genus of the botanical family Apocynaceae. At the concentration of 10mg/ml n-hexane 338.725mg/g, ethyl acetate 388.627mg/g and 400.196mg/g respectively with an equivalence to quercetin content [17]. In India, it is commonly found in hedges through cut most of cenfry to an altitude about 1000m in Himalaya and 900m in Southern India. (11). Importantly P. daemia extract have the ability to reduce iron from ferric (Fe3+) to ferrous (Fe2+) and the EC50 value was recorded for extract, ascorbic acid and BHT were 17.78, 0.5239 and 0.2065mg/ml respectively.

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